Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene Transduction
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Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene Transduction
During pancreas development, endocrine precursors and their progeny differentiate, migrate, and cluster to form nascent islets. The transcription factor Neurogenin 3 (Neurog3) is required for islet development in mice, but its role in these dynamic morphogenetic steps has been inferred from fixed tissues. Moreover, little is known about the molecular genetic functions of NEUROG3 in human islet ...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2015
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db15-0042